2-Amino-2-methyl-1,3-propanediol → 4,8-bis-(2-chloro-phenyl)-2-(2-hydroxy-1-hydroxymethyl-1-methyl-ethylamino)-8H-pyrido[2,3-d]pyrimidin-7-one

反応式

[Cl:1][c:2]1[c:3](-[c:8]2[c:9]3[c:10]([n:11][c:12]([S:14]([CH3:15])(=[O:16])=[O:17])[n:13]2)[n:18](-[c:23]2[c:24]([Cl:29])[cH:25][cH:26][cH:27][cH:28]2)[c:19](=[O:22])[cH:20][cH:21]3)[cH:4][cH:5][cH:6][cH:7]1.[NH2:30][C:31]([CH2:32][OH:33])([CH2:34][OH:35])[CH3:36]>>[Cl:1][c:2]1[c:3](-[c:8]2[c:9]3[c:10]([n:11][c:12]([NH:30][C:31]([CH2:32][OH:33])([CH2:34][OH:35])[CH3:36])[n:13]2)[n:18](-[c:23]2[c:24]([Cl:29])[cH:25][cH:26][cH:27][cH:28]2)[c:19](=[O:22])[cH:20][cH:21]3)[cH:4][cH:5][cH:6][cH:7]1

参加物

反応物 2

HCID 15312-Amino-2-methyl-1,3-propanediol

HCID 102255784,8-bis-(2-chloro-phenyl)-2-methanesulfonyl-8H-pyrido[2,3-d]pyrimidin-7-one

生成物 1

HCID 102989324,8-bis-(2-chloro-phenyl)-2-(2-hydroxy-1-hydroxymethyl-1-methyl-ethylamino)-8H-pyrido[2,3-d]pyrimidin-7-one

出典と根拠

ORDレコード: ord-044f4be5bf2e45eb87ca02d3b044fbbd
出典データセット: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…