Ammonium Acetate → 4,5,6,7-Tetrahydro-1-benzofuran-4-amine

HRID 1612155

反応式

HRID 1612155 の反応式
[O:1]1[C:5]2[CH2:6][CH2:7][CH2:8][C:9](=O)[C:4]=2[CH:3]=[CH:2]1.C([O-])(=O)C.[NH4+].C([BH3-])#[N:17].[Na+]>CO>[O:1]1[C:5]2[CH2:6][CH2:7][CH2:8][CH:9]([NH2:17])[C:4]=2[CH:3]=[CH:2]1

参加物

5

反応物 3

HCID 517165Ammonium AcetateHCID 27335414,5,6,7-Tetrahydro-1-benzofuran-4-oneHCID 5003444Sodium cyanoborohydride

生成物 1

HCID 185251714,5,6,7-Tetrahydro-1-benzofuran-4-amine収率 38%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 6,7-dihydro-1-benzofuran-4(5H)-one (2.0 g) in methanol (50 ml) was added 3 Å sieves (15 g), ammonium acetate (11.3 g) and sodium cyanoborohydride (1.22 g). After 48 h of stirring, the reaction mixture was filtered through celite, concentrated, dissolved in 1 N HCl (100 ml) and washed with ethyl ether (3×100 ml). The Aqueous layer was basified to pH 10 (NaOH), extracted methylene chloride (3×100 ml), dried MgSO4, filtered and concentrated to yield (760 mg, 38%) of the title compound as an oil:

後処理

  1. filtrationthe reaction mixture was filtered through celite
  2. concentrationconcentrated
  3. dissolutiondissolved in 1 N HCl (100 ml)
  4. washwashed with ethyl ether (3×100 ml)
  5. extractionextracted methylene chloride (3×100 ml), dried MgSO4
  6. filtrationfiltered
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-3f6bba7a59fd4951a184dd8095483adf
出典データセット
uspto-grants-2006_01
特許番号
US06992087B2

関連ノート

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