3-Nitro-5-(2-oxopyrrolidin-1-yl)benzoic acid → 3-Amino-5-(2-oxo-pyrrolidin-1-yl)-benzoic acid
反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[C:11]([N:13]2[CH2:17][CH2:16][CH2:15][C:14]2=[O:18])[CH:12]=1)[C:7]([OH:9])=[O:8])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH:10]=[C:11]([N:13]2[CH2:17][CH2:16][CH2:15][C:14]2=[O:18])[CH:12]=1)[C:7]([OH:9])=[O:8]参加物
4
実験手順
A mixture of 3-nitro-5-(2-oxopyrrolidin-1-yl)-benzoic acid (D5) (2.86 g) and 10% Pd—C (0.7 g) in methanol (450 ml) water (50 ml) was hydrogenated at atmospheric pressure for 3 hrs. The mixture was filtered through Celite and concentrated to give 3-amino-5-(2-oxopyrrolidin-1-yl)-benzoic acid (2.70 g).
後処理
- filtrationThe mixture was filtered through Celite
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-e5e74262b62e4c76ae517cbf2580bf74
- 出典データセット
- uspto-grants-2006_01
- 特許番号
- US06992103B2
反応ノート
読み込み中…