Water → 5-(2-Oxopyrrolidin-1-yl)-biphenyl-3-carboxylic Acid

HRID 1612437ノート

反応式

HRID 1612437 の反応式
C[O:2][C:3]([C:5]1[CH:6]=[C:7]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:8]=[C:9]([N:11]2[CH2:15][CH2:14][CH2:13][C:12]2=[O:16])[CH:10]=1)=[O:4].[Li+].[OH-].O>O1CCOCC1>[O:16]=[C:12]1[CH2:13][CH2:14][CH2:15][N:11]1[C:9]1[CH:10]=[C:5]([C:3]([OH:4])=[O:2])[CH:6]=[C:7]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:8]=1

参加物

5

反応物 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 695897705-(2-Oxopyrrolidin-1-yl)-biphenyl-3-carboxylic Acid Methyl Ester

生成物 1

HCID 222529945-(2-Oxopyrrolidin-1-yl)-biphenyl-3-carboxylic Acid

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To 5-(2-oxopyrrolidin-1-yl)-biphenyl-3-carboxylic acid methyl ester (D10) (23 mg, 0.078 mmol) in dioxane (2 ml) was added LiOH (5 mg, 0.117 mmol) and water (1 ml) and stirred at room temperature for 2 hours. The solvent was then evaporated to dryness and the residue was partitioned between ethyl acetate and water. The aqueous layer was separated and acidified to pH=1. The product precipitated in the aqueous layer and was removed by filtration and dried in vacuo to afford D11 (10 mg) as white solid.

後処理

  1. customThe solvent was then evaporated to dryness
  2. customthe residue was partitioned between ethyl acetate and water
  3. customThe aqueous layer was separated
  4. customThe product precipitated in the aqueous layer
  5. customwas removed by filtration
  6. customdried in vacuo
  7. customto afford D11 (10 mg) as white solid

出典と根拠

ORDレコード
ord-d90817cd960e4005afaad5d26f2c7547
出典データセット
uspto-grants-2006_01
特許番号
US06992103B2

反応ノート

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