Lithium Hydroxide → 3-(2-Oxo-1,3-oxazolidin-3-yl)benzoic acid

HRID 1612442ノート

反応式

HRID 1612442 の反応式
C[O:2][C:3](=[O:16])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N:10]2[CH2:14][CH2:13][O:12][C:11]2=[O:15])[CH:5]=1.[Li+].[OH-]>O1CCOCC1>[O:15]=[C:11]1[N:10]([C:6]2[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=2)[C:3]([OH:16])=[O:2])[CH2:14][CH2:13][O:12]1

参加物

4

反応物 2

HCID 3939Lithium HydroxideHCID 695897133-(2-Oxooxazolidin-3-yl)benzoic Acid Methyl Ester

生成物 1

HCID 222530423-(2-Oxo-1,3-oxazolidin-3-yl)benzoic acid収率 60%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

3-(2-Oxooxazolidin-3-yl)benzoic acid methyl ester (D118) (110 mg, 0.5 mmol) in dioxane (2.5 ml) was treated with 1M LiOH solution (0.75 ml) and the mixture was stirred at room temperature for 1.5 h. Amberlyst 15 was then added and stirring continued for 15 mins. The resin was filtered and the filtrate evaporated to dryness. Th residue was tritutated with diethyl ether to afford the title compound (62 mg, 60%).

後処理

  1. additionAmberlyst 15 was then added
  2. stirringstirring
  3. waitcontinued for 15 mins
  4. filtrationThe resin was filtered
  5. customthe filtrate evaporated to dryness

出典と根拠

ORDレコード
ord-e46ad5cceda64c598328ea23b390abf7
出典データセット
uspto-grants-2006_01
特許番号
US06992103B2

反応ノート

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