p-Toluenesulfonic acid → HCID 178442763、化合物

HRID 1612601

反応式

HRID 1612601 の反応式
C([C@H]1CC[C@H]([C:12]([NH:14][C:15]2[CH:20]=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([CH2:27][CH2:28][CH2:29]CCCCCCC)=[CH:23][CH:22]=3)[CH:18]=[CH:17][C:16]=2O)=[O:13])CC1)CCCC.[C:38]1([CH3:48])[CH:43]=[CH:42][C:41](S(O)(=O)=O)=[CH:40][CH:39]=1.Cl[C:50]1[CH:55]=[CH:54][CH:53]=[CH:52][C:51]=1Cl>>[CH2:17]([C@H:50]1[CH2:55][CH2:54][C@H:53]([C:12]2[O:13][C:16]3[CH:17]=[CH:18][C:19]([C:21]4[CH:26]=[CH:25][C:24]([CH2:27][CH2:28][CH2:29][CH2:48][CH2:38][CH2:43][CH2:42][CH2:41][CH2:40][CH3:39])=[CH:23][CH:22]=4)=[CH:20][C:15]=3[N:14]=2)[CH2:52][CH2:51]1)[CH2:16][CH2:15][CH2:20][CH3:19]

参加物

4

反応物 3

HCID 6101p-Toluenesulfonic acidHCID 72391,2-Dichlorobenzene2 回HCID 178442765HCID 178442765、化合物

生成物 1

HCID 178442763HCID 178442763、化合物収率 48.4%

実験手順

Step ii) In a 30 ml-round-bottomed flask, 0.60 g (1.19 mM) of 2-(trans-4-pentylcyclohexylcarbonylamino)-4-(4decylphenyl)phenol, 0.07 g (0.37 mM) of p-toluenesulfonic acid and 10 ml of o-dichlorobenzene were placed, followed by stirring for 40 min. at 188°-192° C. After the reaction, o-dichlorobenzene was distilled-off under reduced pressure. The residue was purified by silica gel column chromatography (eluent: toluene) to obtain 0.28 g of 2-(trans-4-pentylcyclohexyl)-5-(4-decylphenyl)benzoxazole (yield: 48.4%). ##STR100##

後処理

  1. customThe residue was purified by silica gel column chromatography (eluent: toluene)

出典と根拠

ORDレコード
ord-9db51813f0624f6db8f3cb4665e14fcd
出典データセット
uspto-grants-1993_03
特許番号
US05190690

関連ノート

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