Water → N-(2,3-Dihydro-1H-inden-2-yl)formamide

HRID 1612892ノート

反応式

HRID 1612892 の反応式
[NH2:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1.[C:11](O)(=[O:13])C.C(OC=O)=O.O>O1CCCC1>[CH:11]([NH:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1)=[O:13]

参加物

5

反応物 3

HCID 962WaterHCID 763102-AminoindaneHCID 86740153HCID 86740153、化合物

生成物 1

HCID 14835235N-(2,3-Dihydro-1H-inden-2-yl)formamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a solution of 2-aminoindan (19.95 g) in tetrahydrofuran is added an solution of 2M acetic acid-formic acid anhydride in tetrahydrofuran under ice cooling, and the mixture is reacted at room temperature. To the reaction mixture is added water, and then, the solvent is distilled off, and the residue is extracted with ethyl acetate. After distilling off the solvent, the residue is recrystallized from ethyl acetate - n-hexane to give 2-formylaminoindan (19.02 g).

後処理

  1. customthe mixture is reacted at room temperature
  2. distillationthe solvent is distilled off
  3. extractionthe residue is extracted with ethyl acetate
  4. distillationAfter distilling off the solvent
  5. customthe residue is recrystallized from ethyl acetate - n-hexane

出典と根拠

ORDレコード
ord-ac733324afe24761bce9d742b143df13
出典データセット
uspto-grants-1993_03
特許番号
US05190975

反応ノート

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