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N,N,N-trimethylglycinium → (-)-Carnitine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N,N,N-trimethylglycinium | HCID 248 | — |
| 反応物 | Carnitine Chloride | HCID 5970 | — |
| 反応物 | (2R)-3-Cyano-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride | HCID 200829 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 生成物 | (-)-Carnitine | HCID 10917 | — |
反応手順
13.5 kg L-carnitine nitrile chloride was dissolved in 22 liters concentrated hydrochloric acid and hydrolyzed to L-carnitine chloride, as described in Example 2. It was subsequently reacted to betaine in the highly basic ion exchanger (Amberlite IRA-416). After appropriate reprocessing, 11.1 kg colorless L-carnitine with (α)D20 =-30.8° and an HPLC concentration of 99.7% was isolated.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05191085 |
| 出典データセット | uspto-grants-1993_03 |
| ORD ID | ord-62087cc445b44d86996435c802aaa79a |
| 出典メモ | uspto-grants-1993_03 |