Thioacetamide → HCID 19775571、化合物

HRID 1613230ノート

反応式

HRID 1613230 の反応式
Cl[CH:2]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][CH:8]=1)[C:3](=O)[CH3:4].[C:16]([NH2:19])(=[S:18])[CH3:17]>C(O)C.CCCCC>[CH3:17][C:16]1[S:18][C:2]([CH2:6][C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][CH:8]=2)=[C:3]([CH3:4])[N:19]=1

参加物

5

反応物 2

HCID 2723949ThioacetamideHCID 19775550HCID 19775550、化合物

生成物 1

HCID 19775571HCID 19775571、化合物収率 68.3%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 8003Pentane溶媒

実験手順

4.7 g of 3-chloro-4-(4-nitrophenyl)butan-2-one and 2.4 g of thioacetamide are dissolved in 60 ml of ethanol and refluxed for 12 hours. The reaction medium is concentrated, the residue is taken up in water and the solution is rendered basic with sodium carbonate and extracted with chloroform. After concentration of the organic phase, the solid obtained is taken up in hot pentane to give 3.5 g of 2,4-dimethyl-5-(4-nitrobenzyl)thiazole in the form of yellow crystals melting at 66° C.

後処理

  1. temperaturerefluxed for 12 hours
  2. concentrationThe reaction medium is concentrated
  3. extractionextracted with chloroform
  4. customAfter concentration of the organic phase, the solid obtained

出典と根拠

ORDレコード
ord-3a57211ae5f14641b84657733032337c
出典データセット
uspto-grants-1993_03
特許番号
US05192781

反応ノート

読み込み中…