Iodoethane → 4-Acetylaminomethyl-1-ethylpyridinium iodide

HRID 1613289ノート

反応式

HRID 1613289 の反応式
[C:1]([NH:4][CH2:5][C:6]1[CH:11]=[CH:10][N:9]=[CH:8][CH:7]=1)(=[O:3])[CH3:2].[CH2:12]([I:14])[CH3:13]>CC(C)=O>[I-:14].[C:1]([NH:4][CH2:5][C:6]1[CH:7]=[CH:8][N+:9]([CH2:12][CH3:13])=[CH:10][CH:11]=1)(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 6340IodoethaneHCID 289830N-(4-Pyridinylmethyl)acetamide

生成物 1

HCID 197755294-Acetylaminomethyl-1-ethylpyridinium iodide

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A solution of 4-acetylaminomethylpyridine (22.40 g) and ethyl iodide (17.9 ml) in acetone (300 ml) was heated under reflux for 24 hours and then the solvent was evaporated in vacuo. The residue was washed with a mixture of n-hexane, ethyl acetate and ethanol to give very hygroscopic 4-acetylaminomethyl-1-ethylpyridinium iodide (42.18 g), which was used without further purification.

後処理

  1. temperatureunder reflux for 24 hours
  2. customthe solvent was evaporated in vacuo
  3. washThe residue was washed with a mixture of n-hexane, ethyl acetate and ethanol

出典と根拠

ORDレコード
ord-72871ffb1d7949a193402c3c0e64480b
出典データセット
uspto-grants-1993_03
特許番号
US05192779

反応ノート

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