2-Chloroethanol → 2-(4-Methoxyphenoxy)ethanol
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1.Cl[CH2:11][CH2:12][OH:13].[OH-].[Na+]>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH2:11][CH2:12][OH:13])=[CH:5][CH:4]=1参加物
5
実験手順
A mixture of 148.8 g (1.20 mole) of p-methoxyphenol, 170 g (2.11 mole) of 2-chloroethanol and 47.2 g (1.18 mole) of sodium hydroxide in 1.5 liter of absolute ethanol was heated at reflux for 22 hr. The solution was filtered, and the solvent was removed from the filtrate in vacuo. The residue was crystallized from methylene chloride-hexane to give 71.4 g (35%) of title compound as a white crystalline solid, mp 69°-71° C.
後処理
- temperaturewas heated
- temperatureat reflux for 22 hr
- filtrationThe solution was filtered
- customthe solvent was removed from the filtrate in vacuo
- customThe residue was crystallized from methylene chloride-hexane
出典と根拠
- ORDレコード
- ord-d87b6a85935f400596a7a04e3e61541a
- 出典データセット
- uspto-grants-1993_03
- 特許番号
- US05192785
反応ノート
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