Hydrochloric Acid → 3-Methyl-2-furoic acid

HRID 1614026ノート

反応式

HRID 1614026 の反応式
[CH3:1][C:2]1[CH:6]=[CH:5][O:4][C:3]=1[C:7]([O:9]C)=[O:8].[OH-].[Na+].Cl>>[CH3:1][C:2]1[CH:6]=[CH:5][O:4][C:3]=1[C:7]([OH:9])=[O:8]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 350231Methyl 3-methyl-2-furoate

生成物 1

HCID 781273-Methyl-2-furoic acid

実験手順

A mixture of 3-methyl-2-furoic acid, methyl ester [20.0 g, 0.14 mole, 0.14 mole, Organic Synthesis 39, 49 (1959)] and 20% NaOH solution (46 mL) was refluxed under argon for 2 hours. The cooled mixture was acidified with concentrated HCl (28.5 mL). The resulting white precipitate was collected, washed with water and dried in vacuo to give the title acid (16.53 g, 94%) as a white crystalline solid, mp 132-134° C.

後処理

  1. temperaturewas refluxed under argon for 2 hours
  2. customThe resulting white precipitate was collected
  3. washwashed with water
  4. customdried in vacuo
  5. customto give the title acid (16.53 g, 94%) as a white crystalline solid, mp 132-134° C.

出典と根拠

ORDレコード
ord-0640bd4eaba044b8a2a4fe4b06bfe2f7
出典データセット
uspto-grants-1993_03
特許番号
US05194634

反応ノート

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