Hydrochloric Acid → Tert-butyl 2-difluoromethoxyimino-3-oxobutyrate

反応式

[F:1][CH:2]([F:22])[O:3][N:4]=[C:5]([C:13](=NC1C=CC=CC=1)[CH3:14])[C:6]([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7].Cl.[O:24]1CCCC1>>[F:1][CH:2]([F:22])[O:3][N:4]=[C:5]([C:13](=[O:24])[CH3:14])[C:6]([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7]

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 8028Tetrahydrofuran

HCID 54271622Tert-butyl 2-difluoromethoxyimino-3-phenyliminobutyrate

生成物 1

HCID 54363554Tert-butyl 2-difluoromethoxyimino-3-oxobutyrate

反応条件

温度: 20 °C

実験手順

To a solution of tert-butyl 2-difluoromethoxyimino-3-phenyliminobutyrate (0.76 g) in tetrahydrofuran (3.8 ml) was added 1N hydrochloric acid (3.64 ml) under ice-cooling. After being stirred at 20° C. for 1.5 hours, the mixture was extracted with ethyl acetate. The separated organic layer was washed with water three times, dried over magnesium sulfate and concentrated under reduced pressure to give tert-butyl 2-difluoromethoxyimino-3-oxobutyrate (0.55 g).