Barbituric Acid → chlorouracil E

HRID 16143

反応式

HRID 16143 の反応式
P(Cl)(Cl)([Cl:3])=O.[NH:6]1[C:13](=[O:14])[CH2:12][C:10](=O)[NH:9][C:7]1=[O:8]>O>[Cl:3][N:6]1[C:13](=[O:14])[CH:12]=[CH:10][NH:9][C:7]1=[O:8]

参加物

4

反応物 2

HCID 6211Barbituric AcidHCID 24813Phosphorus oxychloride

生成物 1

HCID 20083756chlorouracil E

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Phosphoryl chloride (55 ml) is carefully added to barbituric acid (10 g, 78.1 mmol) at 0° C. Water (1.7 ml) is then added dropwise such that the temperature does not exceed 5° C. The mixture is boiled under reflux for 5 h and, after it has cooled down, poured onto ice. The product is extracted with ethyl acetate (3×100 ml) and dried (Na2 SO4). The mixture is filtered and the solvent is distilled off in vacuo.

後処理

  1. customdoes not exceed 5° C
  2. temperatureunder reflux for 5 h
  3. temperatureafter it has cooled down
  4. additionpoured onto ice
  5. extractionThe product is extracted with ethyl acetate (3×100 ml)
  6. customdried (Na2 SO4)
  7. filtrationThe mixture is filtered
  8. distillationthe solvent is distilled off in vacuo

出典と根拠

ORDレコード
ord-6114b1af78d34b06bd69b96fd94d0f90
出典データセット
uspto-grants-2010_06
特許番号
US07737144B2

関連ノート

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