Water → HCID 19773825、化合物

HRID 1614416ノート

反応式

HRID 1614416 の反応式
[F:1][C:2]1[C:9]([F:10])=[CH:8][C:7]([C:11]([F:14])([F:13])[F:12])=[CH:6][C:3]=1[C:4]#N.[OH-:15].[Na+].[OH2:17]>>[F:1][C:2]1[C:9]([F:10])=[CH:8][C:7]([C:11]([F:14])([F:13])[F:12])=[CH:6][C:3]=1[C:4]([OH:17])=[O:15]

参加物

4

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 190908472,3-Difluoro-5-(trifluoromethyl)benzonitrile

生成物 1

HCID 19773825HCID 19773825、化合物

反応条件

温度
97 °C

実験手順

2,3-Difluoro-5-(trifluoromethyl)benzonitrile (60.03 g, 0.29 moles) is added to a solution of 17.5 g (0.43 moles) of sodium hydroxide in 158 ml of water. The mixture is heated to 97° C. during 1 hour and then heating is continued for an additional 2 hours. The mixture is acidified and the solid acid filtered off and air dried to yield 2,3-difluoro-5-(trifluoromethyl)benzoic acid, m.p. 94°-96° C.

後処理

  1. temperatureheating
  2. filtrationthe solid acid filtered off
  3. customair dried

出典と根拠

ORDレコード
ord-1b2cceb66a7242cca6461361e0ade2d9
出典データセット
uspto-grants-1993_03
特許番号
US05196593

反応ノート

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