Hydrochloric Acid → 1,2-Diamino-1-benzyloxymethyl-ethane-dihydrochloride
反応式
[NH2:1][CH:2](N1C(=O)C2=CC=CC=C2C1=O)[CH2:3][CH2:4][O:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.O.[NH2:25]N.[ClH:27]>CO>[ClH:27].[ClH:27].[NH2:25][CH:3]([CH2:4][O:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH2:2][NH2:1]参加物
5
実験手順
1-Amino-2-benzyloxymethyl-1-phthalimido-ethane (3.0 g, 9.7 mmol) is dissolved in 50 ml dry methanol and hydrazine hydrate (968 mg, 19.3 mmol) is added. After being refluxed for 4 hours, the reaction mixture is stirred for 24 hours at ambient temperature and 50 ml 2N hydrochloric acid was added. The phthalhydrazide is removed by filtration and the 1,2-diamino-1-benzyloxymethyl-ethane-dihydrochloride is purified by recrystallisation from dry ethanol.
後処理
- temperatureAfter being refluxed for 4 hours
- customThe phthalhydrazide is removed by filtration
- customthe 1,2-diamino-1-benzyloxymethyl-ethane-dihydrochloride is purified by recrystallisation from dry ethanol
出典と根拠
- ORDレコード
- ord-01536e3ddfb646a6b6ba9b0732f26e69
- 出典データセット
- uspto-grants-1993_03
- 特許番号
- US05198208
反応ノート
読み込み中…