Hydrogen Bromide → 5-bromo-1,2 dihydro-2,2-dimethyl-6-(2-imidazolin-2-ylamino)-3-(4H)-quinoxalinone

HRID 1614548ノート

反応式

HRID 1614548 の反応式
Br.[NH2:2][C:3]1[C:4]([Br:16])=[C:5]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8]([CH3:14])([CH3:13])[C:7](=[O:15])[NH:6]2.[NH:17]1[CH2:21][CH2:20][N:19]=[C:18]1S(O)(=O)=O.Br>C(O)C(C)C>[Br:16][C:4]1[C:3]([NH:2][C:18]2[NH:19][CH2:20][CH2:21][N:17]=2)=[CH:12][CH:11]=[C:10]2[C:5]=1[NH:6][C:7](=[O:15])[C:8]([CH3:13])([CH3:14])[NH:9]2

参加物

5

反応物 3

HCID 260Hydrogen BromideHCID 2745614,5-dihydro-1H-imidazole-2-sulfonic acidHCID 199364056-Amino-5-bromo-1,2-dihydro-2,2-dimethyl-3-(4h)-quinoxalinone hydrobromide

生成物 1

HCID 152257155-bromo-1,2 dihydro-2,2-dimethyl-6-(2-imidazolin-2-ylamino)-3-(4H)-quinoxalinone

試薬・触媒・溶媒 1

HCID 6560Isobutanol溶媒

実験手順

A mixture of 6-amino-5-bromo-1,2-dihydro-2,2-dimethyl-3-(4H) - quinoxalinone hydrobromide (479 mg, 1 mmol) and 2-imidazoline-2-sulfonic acid (224 mg, 1.5 mmol) in isobutanol (5 ml) is heated at reflux until the starting hydrobromide material is consumed. The solvent is removed in vacuo and the residue chromatographed on silica gel with CHCl3 : CH3OH saturated with NH3 (g) elution to yield the title compound.

後処理

  1. temperatureis heated
  2. customis consumed
  3. customThe solvent is removed in vacuo
  4. customthe residue chromatographed on silica gel with CHCl3
  5. washCH3OH saturated with NH3 (g) elution

出典と根拠

ORDレコード
ord-5e284c4625ad4d8ca1c9e107b11db3fd
出典データセット
uspto-grants-1993_03
特許番号
US05198442

反応ノート

読み込み中…