Topotecan Hydrochloride → Topotecan

HRID 1614849

反応式

HRID 1614849 の反応式
[CH3:1][CH2:2][C@@:3]1([OH:31])[C:8](=[O:9])[O:7][CH2:6][C:5]2[C:10]([N:12]3[C:29](=[CH:30][C:4]1=2)[C:28]1[N:27]=[C:17]2[CH:18]=[CH:19][C:20]([OH:26])=[C:21]([CH2:22][N:23]([CH3:25])[CH3:24])[C:16]2=[CH:15][C:14]=1[CH2:13]3)=[O:11].Cl.[Na].N[C@H](C(O)=O)CS(=O)(O)=O>CO>[CH3:1][CH2:2][C@@:3]1([OH:31])[C:8](=[O:9])[O:7][CH2:6][C:5]2[C:10]([N:12]3[C:29](=[CH:30][C:4]1=2)[C:28]1[N:27]=[C:17]2[CH:18]=[CH:19][C:20]([OH:26])=[C:21]([CH2:22][N:23]([CH3:24])[CH3:25])[C:16]2=[CH:15][C:14]=1[CH2:13]3)=[O:11]

参加物

5

反応物 3

HCID 60699Topotecan HydrochlorideHCID 72886L-Cysteic acidHCID 5360545Sodium

生成物 1

HCID 60700Topotecan

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methanol stock-solutions of topotecan hydrochloride (120 ml, 1.09 mg/ml) and sodium salt of methyl ester of N-all-trans-retinoyl cysteic acid (32 ml, 15 mg/ml) were mixed in a 500 ml round-bottom flask and evaporated in vacuo. 120 ml sodium chloride solution (9 mg/ml) was added to the residue obtained after evaporation, and the mixture was stirred until it became clear and transparent (approx. 20 min). The concentration of topotecan in the obtained solution was 1 mg/ml, corresponding to a topotecan hydrochloride concentration of 1.09 mg/ml. The solution obtained was filtered through 0.2 mm filter. The filtration did not result in reduction of topotecan concentration.

後処理

  1. customevaporated in vacuo
  2. addition120 ml sodium chloride solution (9 mg/ml) was added to the residue
  3. customobtained
  4. customafter evaporation
  5. customtransparent (approx. 20 min)
  6. customThe solution obtained
  7. filtrationwas filtered through 0.2 mm
  8. filtrationfilter
  9. filtrationThe filtration

出典と根拠

ORDレコード
ord-b59c5040c4d74c4eba154504c0cb4c58
出典データセット
uspto-grants-2014_07
特許番号
US08765173B2

関連ノート

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