Water → HCID 66786530、化合物

HRID 1615055ノート

反応式

HRID 1615055 の反応式
[CH3:1][C:2]1([CH3:9])[O:6][C@H:5]([CH2:7][OH:8])[CH2:4][O:3]1.[H-].[Na+].CS(OC[C:18]1[CH:23]=[CH:22][N:21]=[C:20]([C:24]([N:26]2[CH2:29][CH:28]([C:30]3[CH:35]=[CH:34][C:33]([O:36][CH2:37][C:38]4[CH:43]=[CH:42][C:41]([CH:44]5[CH2:46][CH2:45]5)=[CH:40][CH:39]=4)=[C:32]([O:47][CH3:48])[CH:31]=3)[CH2:27]2)=[O:25])[CH:19]=1)(=O)=O.O.[CH3:50]N(C=O)C>>[CH:44]1([C:41]2[CH:40]=[CH:39][C:38]([CH2:37][O:36][C:33]3[CH:34]=[CH:35][C:30]([CH:28]4[CH2:29][N:26]([C:24]([C:20]5[CH:19]=[C:18]([C@H:7]([CH:5]6[CH2:4][O:3][C:2]([CH3:9])([CH3:1])[O:6]6)[O:8][CH3:50])[CH:23]=[CH:22][N:21]=5)=[O:25])[CH2:27]4)=[CH:31][C:32]=3[O:47][CH3:48])=[CH:43][CH:42]=2)[CH2:46][CH2:45]1

参加物

6

反応物 5

HCID 962WaterHCID 6228DimethylformamideHCID 24758Sodium hydrideHCID 736056(R)-SolketalHCID 59634043HCID 59634043、化合物2 回

生成物 1

HCID 66786530HCID 66786530、化合物

実験手順

To a solution of (R)-(−)-2,2-dimethyl-1,3-dioxolan-4-methanol (0.42 mL) in DMF (10 mL) was added NaH (0.14 g). The mixture was stirred at RT for 1 hr. To the mixture was added 2-{3-[4-(4-cyclopropylbenzyloxy)-3-methoxyphenyl]azetidine-1-carbonyl}pyridin-4-ylmethyl methanesulfonate (0.80 g) prepared in (7). The reaction mixture was stirred for at RT for 1 hr. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was washed with water, reduced pressure to give the crude title compound.

後処理

  1. stirringThe reaction mixture was stirred for at RT for 1 hr
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with water, reduced pressure

出典と根拠

ORDレコード
ord-2aee4bf1dc3e43af89e60c2291d7ff11
出典データセット
uspto-grants-2014_07
特許番号
US08765739B2

反応ノート

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