Hydrogen Peroxide → HCID 59634007、化合物

HRID 1615088ノート

反応式

HRID 1615088 の反応式
[Si:1]([O:8][CH2:9][C:10]([C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1)([F:12])[F:11])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[OH:19]O.O>C(Cl)(Cl)Cl.C[Re](=O)(=O)=O.[O-2].[Mn+4].[O-2]>[Si:1]([O:8][CH2:9][C:10]([C:13]1[CH:18]=[CH:17][N+:16]([O-:19])=[CH:15][CH:14]=1)([F:12])[F:11])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

参加物

7

反応物 3

HCID 784Hydrogen PeroxideHCID 962WaterHCID 59633930HCID 59633930、化合物2 回

生成物 1

HCID 59634007HCID 59634007、化合物

試薬・触媒・溶媒 3

HCID 178418406HCID 178418406、化合物触媒HCID 178477782HCID 178477782、化合物触媒HCID 6212Chloroform溶媒

実験手順

To a solution of 4-[2-(tert-butyldimethylsilanyloxy)-1,1-difluoroethyl]pyridine (0.14 g) prepared in (3) in chloroform (3 mL) were added methyltrioxorhenium (VII) (0.0010 g) and aqueous 30% hydrogen peroxide (0.11 mL). The reaction mixture was stirred at RT for 4 hr. To the mixture was added manganese (IV) oxide. The reaction mixture was stirred at RT for 1 hr. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was dried over MgSO4. The solvent was removed under reduced pressure to give the crude title compound.

後処理

  1. stirringThe reaction mixture was stirred at RT for 1 hr
  2. extractionthe mixture was extracted with ethyl acetate
  3. dry with materialThe organic layer was dried over MgSO4
  4. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-2bb54548753147d6be282a2d499fa580
出典データセット
uspto-grants-2014_07
特許番号
US08765739B2

反応ノート

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