tert-butyl 5-(4-(methoxycarbonyl)phenyl)-2H-1,4-oxazine-4(3H)-carboxylate → Tert-butyl 3-(4-(methoxycarbonyl)phenyl)morpholine-4-carboxylate
反応式
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][CH2:14][O:15][CH:16]=2)=[CH:7][CH:6]=1)=[O:4]>CO.[OH-].[OH-].[Pd+2]>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]([CH:11]2[CH2:16][O:15][CH2:14][CH2:13][N:12]2[C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[CH:9][CH:10]=1)=[O:4]参加物
4
実験手順
To a mixture of tert-butyl 5-(4-(methoxycarbonyl)phenyl)-2H-1,4-oxazine-4(3H)-carboxylate (50 mg, 0.156 mmol) in methanol (3 ml) was added Pd(OH)2/C (25 mg). The mixture was stirred under a hydrogen for 18 hrs. The mixture was filtered and concentrated to give the title compound as a yellow oil (47.6 mg, 95%). Data was identical to that described below.