Sodium Hydroxide → sodium 2-(5-amino-3-phenyl-4-(phenylethynyl)-1H-pyrazol-1-yl)acetate
反応式
C([NH:4][C:5]1[N:9]([CH2:10][C:11]([O:13]CC)=[O:12])[N:8]=[C:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:6]=1[C:22]#[C:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)(=O)C.[OH-].[Na+:31]>C(O)C>[NH2:4][C:5]1[N:9]([CH2:10][C:11]([O-:13])=[O:12])[N:8]=[C:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:6]=1[C:22]#[C:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.[Na+:31]参加物
4
反応条件
- 温度
- 80 °C
実験手順
A mixture of ethyl 2-[5-acetamido-3-phenyl-4-(2-phenylethynyl)pyrazol-1-yl]acetate (13 g, 34 mmol), ethanol (150 mL) and 25% aq. NaOH solution (150 mL) was stirred and heated to 80° C. for 8 h and cooled to room temperature. Upon cooling, a precipitate formed. The precipitate was filtered and washed with cooled mixture of ethyl acetate/water (1:1). The solid was further triturated with diethyl ether, filtered and dried to provide 9.8 g of the title compound.