Sodium Hydroxide → 2-(1-(Tert-butoxycarbonyl)-3-(4-fluorophenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)ethanoic acid

HRID 1615753ノート

反応式

HRID 1615753 の反応式
[OH-].[Na+].[F:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[N:15]([CH2:16][C:17]([O:19]C)=[O:18])[C:14](=[O:21])[C:13]3([CH2:27][O:26][CH2:25][CH2:24][O:23][CH2:22]3)[N:12]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:11]2)=[CH:6][CH:5]=1>CO>[C:31]([O:30][C:28]([N:12]1[C:13]2([CH2:27][O:26][CH2:25][CH2:24][O:23][CH2:22]2)[C:14](=[O:21])[N:15]([CH2:16][C:17]([OH:19])=[O:18])[CH:10]([C:7]2[CH:6]=[CH:5][C:4]([F:3])=[CH:9][CH:8]=2)[CH2:11]1)=[O:29])([CH3:34])([CH3:32])[CH3:33]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 68154635Tert-butyl 3-(4-fluorophenyl)-4-(2-methoxy-2-oxoethyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecane-1-carboxylate

生成物 1

HCID 681545962-(1-(Tert-butoxycarbonyl)-3-(4-fluorophenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)ethanoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2.0 ml (2.0 mmol) of a 1N aqueous sodium hydroxide solution were added to 0.29 mg (0.61 mmol) tert-butyl 3-(4-fluorophenyl)-4-(2-methoxy-2-oxoethyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecane-1-carboxylate in 5 ml MeOH. After 1 h at RT MeOH was distilled off and the aqueous solution was acidified with 1N hydrochloric acid. The aqueous phase was extracted with ethyl acetate. The ethyl acetate phase was dried and evaporated down.

後処理

  1. distillationAfter 1 h at RT MeOH was distilled off
  2. extractionThe aqueous phase was extracted with ethyl acetate
  3. dry with materialThe ethyl acetate phase was dried
  4. customevaporated down

出典と根拠

ORDレコード
ord-691fccf8d85746ff902c488daf28e7df
出典データセット
uspto-grants-2014_07
特許番号
US08765763B2

反応ノート

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