Methanol → HCID 13221873、化合物
反応式
S(Cl)([Cl:3])=O.[CH3:5][C:6]([NH2:12])([C:9]([OH:11])=[O:10])[CH2:7][OH:8].[CH3:13]O>>[ClH:3].[CH3:5][C@@:6]([C:9]([O:11][CH3:13])=[O:10])([CH2:7][OH:8])[NH2:12]参加物
4
実験手順
Thionyl chloride (12.8 mL, 175 mmol) was added dropwise to a stirred suspension of DL-2-methylserine hydrate, (10.4 g, 88.0 mmol) in anhydrous methanol (67 mL) at 0° C. The solids gradually dissolved during the addition. Upon complete addition the bath was removed and the mixture stirred at room temperature overnight. The solvent was then removed in vacuo to give an oil which was azeotroped twice with ether and further dried under vacuum to give the title compound.
後処理
- dissolutionThe solids gradually dissolved during the addition
- additionUpon complete addition the bath
- customwas removed
- customThe solvent was then removed in vacuo
- customto give an oil which
- customwas azeotroped twice with ether
- customfurther dried under vacuum
出典と根拠
- ORDレコード
- ord-93fdb3b54c564339aafbd7d6202866d0
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08765759B2
反応ノート
読み込み中…