N-cyclohexyl-N'-(2-morpholinoethyl)-carbodiimide methyl-p-toluenesulfonate → 4-Methoxy-9-aza-tricyclo[6.3.1.0*2,7*]dodeca-2,4,6-trien-10-one

HRID 1616650

反応式

HRID 1616650 の反応式
[Cl-].[C:2]([CH2:5][CH:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH3:16])[CH:13]=2)[CH:8]([NH3+:17])[CH2:7]1)(O)=[O:3].COS(C1C=CC(C)=CC=1)(=O)=O.C1(N=C=NCCN2CCOCC2)CCCCC1>N1C=CC=CC=1>[CH3:16][O:15][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][CH:11]=1)[CH:8]1[CH2:7][CH:6]2[CH2:5][C:2](=[O:3])[NH:17]1

参加物

4

反応物 2

HCID 9954069N-cyclohexyl-N'-(2-morpholinoethyl)-carbodiimide methyl-p-toluenesulfonateHCID 86656208HCID 86656208、化合物

生成物 1

HCID 669417754-Methoxy-9-aza-tricyclo[6.3.1.0*2,7*]dodeca-2,4,6-trien-10-one

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

3-Carboxymethyl-5-methoxy-indan-1-yl-ammonium chloride (13.2 g) and 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide methyl-p-toluenesulfonate (21.7 g) dissolved in pyridine (500 mL) are stirred at room temperature for 7 d. Then, the pyridine is removed under reduced pressure and the residue is taken up in water (200 mL) and dichloromethane (200 mL). The organic phase is separated and the aqueous phase is extracted twice with dichloromethane. The combined organic phases are washed with 1 M hydrochloric acid, 1 M NaOH solution, and water. After drying (MgSO4), the solvent is evaporated under reduced pressure to yield the product as a beige solid.

後処理

  1. customThen, the pyridine is removed under reduced pressure
  2. customThe organic phase is separated
  3. extractionthe aqueous phase is extracted twice with dichloromethane
  4. washThe combined organic phases are washed with 1 M hydrochloric acid, 1 M NaOH solution, and water
  5. dry with materialAfter drying (MgSO4)
  6. customthe solvent is evaporated under reduced pressure

出典と根拠

ORDレコード
ord-b96a7ee837fb482a927988a49d3863cb
出典データセット
uspto-grants-2014_07
特許番号
US08765780B2

関連ノート

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