Dihydro-2-methyl-3(2H)-furanone → 7-Iodo-2'-methyl-3,4,4',5'-tetrahydro-2H-spiro[1-benzofuro[2,3-c]pyridine-1,3'-furan]

HRID 1616871

反応式

HRID 1616871 の反応式
[I:1][C:2]1[CH:7]=[CH:6][C:5]2[C:8]3[CH2:19][CH2:18][NH:17][C:11]4([CH2:16]C[CH2:14][O:13][CH2:12]4)[C:9]=3[O:10][C:4]=2[CH:3]=1.I[C:21]1C=CC2C(CCN)=COC=2C=1.CC1C(=O)CCO1>>[I:1][C:2]1[CH:7]=[CH:6][C:5]2[C:8]3[CH2:19][CH2:18][NH:17][C:11]4([CH2:16][CH2:14][O:13][CH:12]4[CH3:21])[C:9]=3[O:10][C:4]=2[CH:3]=1

参加物

4

反応物 3

HCID 18522Dihydro-2-methyl-3(2H)-furanoneHCID 673239207-Iodo-3,4,5',6'-tetrahydro-2H,4'H-spiro[1-benzofuro[2,3-c]pyridine-1,3'-pyran]HCID 67324004HCID 67324004、化合物

生成物 1

HCID 673249457-Iodo-2'-methyl-3,4,4',5'-tetrahydro-2H-spiro[1-benzofuro[2,3-c]pyridine-1,3'-furan]

実験手順

Prepared as described for 7-iodo-3,4,5′,6′-tetrahydro-2H,4′H-spiro[1-benzofuro[2,3-c]pyridine-1,3′-pyran] using 2-(6-iodo-benzofuran-3-yl)-ethylamine and 2-methyldihydrofuran-3(2H)-one. The resulting diasteroisomeric mixture was separated using medium pressure liquid chromatography (140 g amine column) eluting with a gradient of EtOAc in hexanes (from 15% to 70% EtOAc).

後処理

  1. customPrepared
  2. customThe resulting diasteroisomeric mixture was separated
  3. washeluting with a gradient of EtOAc in hexanes (from 15% to 70% EtOAc)

出典と根拠

ORDレコード
ord-16439187e53142078b970499578dedb9
出典データセット
uspto-grants-2014_07
特許番号
US08765779B2

関連ノート

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