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Dihydro-2-methyl-3(2H)-furanone → 7-Iodo-2'-methyl-3,4,4',5'-tetrahydro-2H-spiro[1-benzofuro[2,3-c]pyridine-1,3'-furan]
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dihydro-2-methyl-3(2H)-furanone | HCID 18522 | — |
| 反応物 | 7-Iodo-3,4,5',6'-tetrahydro-2H,4'H-spiro[1-benzofuro[2,3-c]pyridine-1,3'-pyran] | HCID 67323920 | — |
| 反応物 | 2-(6-Iodo-benzofuran-3-yl)-ethylamine | HCID 67324004 | — |
| 生成物 | 7-Iodo-2'-methyl-3,4,4',5'-tetrahydro-2H-spiro[1-benzofuro[2,3-c]pyridine-1,3'-furan] | HCID 67324945 | — |
反応手順
Prepared as described for 7-iodo-3,4,5′,6′-tetrahydro-2H,4′H-spiro[1-benzofuro[2,3-c]pyridine-1,3′-pyran] using 2-(6-iodo-benzofuran-3-yl)-ethylamine and 2-methyldihydrofuran-3(2H)-one. The resulting diasteroisomeric mixture was separated using medium pressure liquid chromatography (140 g amine column) eluting with a gradient of EtOAc in hexanes (from 15% to 70% EtOAc).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08765779B2 |
| 出典データセット | uspto-grants-2014_07 |
| ORD ID | ord-16439187e53142078b970499578dedb9 |
| 出典メモ | uspto-grants-2014_07 |