Dimethylamine → HCID 67325537、化合物

HRID 1616936ノート

反応式

HRID 1616936 の反応式
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([I:11])[C:3]=1[C:4](Cl)=[O:5].[CH3:12][NH:13][CH3:14].C1COCC1>O>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([I:11])[C:3]=1[C:4]([N:13]([CH3:14])[CH3:12])=[O:5]

参加物

5

反応物 3

HCID 674DimethylamineHCID 8028TetrahydrofuranHCID 27786602-Fluoro-6-iodobenzoyl chloride

生成物 1

HCID 67325537HCID 67325537、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

2-Fluoro-6-iodobenzoylchloride 1.0 mL, 6.9 mmol was added dropwise to a solution of dimethylamine in THF (2.0 M 7.0 mL, 10 mmol). The reaction mixture was stirred for 16 h and then transferred into water. The resulting suspension was collected by filtration and dried to afford the title compound as a pale yellow solid. The product was used in the next reaction step without further purification. mp 86-89° C.

後処理

  1. filtrationThe resulting suspension was collected by filtration
  2. customdried

出典と根拠

ORDレコード
ord-13e346a51f62400ca0e456e338df6e46
出典データセット
uspto-grants-2014_07
特許番号
US08765779B2

反応ノート

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