2-Bromopropane → HCID 67323888、化合物
反応式
[Br:1][C:2]1[C:3]([F:9])=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.C(=O)([O-])[O-].[Cs+].[Cs+].Br[CH:17]([CH3:19])[CH3:18]>C(#N)C>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH:17]([CH3:19])[CH3:18])[C:3]=1[F:9]参加物
5
反応条件
- 温度
- 80 °C
実験手順
To a mixture of 3-bromo-2-fluoro-phenol (2 g, 10 mmol) and cesium carbonate (10 g, 40 mmol) in acetonitrile (20 mL) was added 2-bromopropane (4 mL, 50 mmol). The reaction mixture was stirred at 80° C. for 4 h. The mixture was filtered through a plug of Celite and eluted with ethyl acetate. The resulting solution was evaporated. The residue was purified by flash chromatography on silica gel and eluting with hexanes:EtOAc (1:1) to afford the title product (1.7 g).
後処理
- filtrationThe mixture was filtered through a plug of Celite
- washeluted with ethyl acetate
- customThe resulting solution was evaporated
- customThe residue was purified by flash chromatography on silica gel
- washeluting with hexanes:EtOAc (1:1)
出典と根拠
- ORDレコード
- ord-3b4c517765b944678391a94b6620727b
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08765779B2
反応ノート
読み込み中…