Trifluoroacetic acid → 5-(3-Aminopropyl)-6-methyl-N4-pentylpyrimidine-2,4-diamine

HRID 1617123ノート

反応式

HRID 1617123 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9][CH2:10][CH2:11][NH:12]C(=O)OC(C)(C)C)=[C:4]([NH:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[N:3]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:12][CH2:11][CH2:10][CH2:9][C:5]1[C:4]([NH:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[N:3][C:2]([NH2:1])=[N:7][C:6]=1[CH3:8]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86633392tert-Butyl 3-(2-amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)propylcarbamate

生成物 1

HCID 98378705-(3-Aminopropyl)-6-methyl-N4-pentylpyrimidine-2,4-diamine収率 84.6%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The product from step (iv) (3.8 g) was dissolved in DCM (100 mL) and TFA (35 mL) and the reaction mixture stirred at rt for 16 h. The solvent was evaporated and the residue taken up in MeOH. The product was purified via SCX resin to give the subtitle compound 2.3 g.

後処理

  1. customThe solvent was evaporated
  2. customThe product was purified via SCX resin

出典と根拠

ORDレコード
ord-6223fbed4dd548d38224e306f12a9cb3
出典データセット
uspto-grants-2014_07
特許番号
US08765939B2

反応ノート

読み込み中…