Trifluoroacetic acid → (S)-3-(Benzyl((S)-1-phenylethyl)amino)heptanoic acid

HRID 1617136ノート

反応式

HRID 1617136 の反応式
[CH2:1]([N:8]([C@H:22]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH3:23])[C@@H:9]([CH2:18][CH2:19][CH2:20][CH3:21])[CH2:10][C:11]([O:13]C(C)(C)C)=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:1]([N:8]([C@H:22]([C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)[CH3:23])[C@@H:9]([CH2:18][CH2:19][CH2:20][CH3:21])[CH2:10][C:11]([OH:13])=[O:12])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 68104424(S)-tert-Butyl 3-(benzyl((S)-1-phenylethyl)amino)heptanoate

生成物 1

HCID 68414644(S)-3-(Benzyl((S)-1-phenylethyl)amino)heptanoic acid収率 165.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The product from step (ii) (12 g) was dissolved in DCM (40 mL) and TFA (2 mL) and the reaction mixture stirred for 24 h. The solvents were evaporated to give the subtitle compound 17 g.

後処理

  1. customThe solvents were evaporated

出典と根拠

ORDレコード
ord-d8e00b8440594fefb3b469ecc557632e
出典データセット
uspto-grants-2014_07
特許番号
US08765939B2

反応ノート

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