Sodium borohydride → (2-Amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methanol
反応式
[BH4-].[Na+].[NH2:3][C:4]1[N:9]=[C:8]([CH3:10])[C:7]([CH:11]=[O:12])=[C:6]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[N:5]=1>CO>[NH2:3][C:4]1[N:9]=[C:8]([CH3:10])[C:7]([CH2:11][OH:12])=[C:6]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[N:5]=1参加物
4
実験手順
Sodium borohydride (0.6 g) was added to a solution of the product from step (ii) (2 g) in MeOH (30 ml) at 0-5° C. The mixture was warmed to rt, stirred for 3 h then the solvent evaporated under reduced pressure. The residue was partitioned between EtOAc and brine, the organics separated, dried and evaporated under reduced pressure to afford the subtitle compound, 1.78 g.
後処理
- customthe solvent evaporated under reduced pressure
- customThe residue was partitioned between EtOAc and brine
- customthe organics separated, dried
- customevaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-99cd473f76d44ccaa447d27da2008ad4
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08765939B2
反応ノート
読み込み中…