4-Iodopyridine → 2-(9H-Fluoren-9-yl)-1-pyridin-4-yl-ethanone

HRID 1617491ノート

反応式

HRID 1617491 の反応式
[CH:1]1[C:13]2[CH:12]([CH2:14][C:15](N(OC)C)=[O:16])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.I[C:22]1[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=1.[Li]CCCC>C1COCC1>[CH:1]1[C:13]2[CH:12]([CH2:14][C:15]([C:22]3[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=3)=[O:16])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 6094924-IodopyridineHCID 866609452-(9H-Fluoren-9-yl)-N-methoxy-N-methyl-acetamideHCID 178418339Butyllithium

生成物 1

HCID 666665732-(9H-Fluoren-9-yl)-1-pyridin-4-yl-ethanone

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

In analogy to example 55, step 2, from 2-(9H-fluoren-9-yl)-N-methoxy-N-methyl-acetamide and 4-iodopyridine using isopropylmagnesium chloride lithium chloride complex in THF at rt (instead of n-BuLi at −70° C.) was prepared the title compound as yellow oil, MS (ESI+): m/z=286.1 ([M+H]+).

後処理

  1. customat rt
  2. customat −70° C.

出典と根拠

ORDレコード
ord-9b55fd442b5543129a0136d6f4e36a3a
出典データセット
uspto-grants-2014_07
特許番号
US08765730B2

反応ノート

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