Hydrazine hydrate (1:1) → HCID 178424063、化合物
反応式
O.[NH2:2]N.C[N:5](/[CH:7]=[N:8]/[C:9](=O)[C:10]1[CH:15]=[CH:14][C:13]([CH3:16])=[C:12]([I:17])[CH:11]=1)C>C(O)(=O)C>[I:17][C:12]1[CH:11]=[C:10]([C:9]2[NH:8][CH:7]=[N:5][N:2]=2)[CH:15]=[CH:14][C:13]=1[CH3:16]参加物
4
反応条件
- 温度
- 90 °C
実験手順
Hydrazine monohydrate (0.30 g, 6.0 mmol) was added to a stirred solution of (E)-N-((dimethylamino)methylene)-3-iodo-4-methylbenzamide (preparation 48b, 1.20 g, 3.8 mmol) in acetic acid (6 mL) and the mixture was stirred and heated to 90° C. After 2 hours, the mixture was concentrated in vacuo and water and 2N aqueous sodium hydroxide solution were added to the residue. The solid that formed was filtered, washed with water and dried in vacuo to give the title compound (0.98 g, 91%) as a solid.
後処理
- concentrationthe mixture was concentrated in vacuo and water and 2N aqueous sodium hydroxide solution
- additionwere added to the residue
- customThe solid that formed
- filtrationwas filtered
- washwashed with water
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-0be44e35d1214139b6b9b12cd86b53f8
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08772288B2
反応ノート
読み込み中…