Bromine → 2-Bromo-1-(3-bromo-4-methylphenyl)ethanone
反応式
[Br:1]Br.[Br:3][C:4]1[CH:5]=[C:6]([C:11](=[O:13])[CH3:12])[CH:7]=[CH:8][C:9]=1[CH3:10]>C(Cl)(Cl)Cl>[Br:1][CH2:12][C:11]([C:6]1[CH:7]=[CH:8][C:9]([CH3:10])=[C:4]([Br:3])[CH:5]=1)=[O:13]参加物
4
実験手順
A solution of bromine (0.68 mL, 13.3 mmol) in chloroform (13 mL) was added dropwise over a 35 minute period to a stirred solution of 1-(3-bromo-4-methylphenyl)ethanone (2.96 g, 13.9 mmol) in chloroform (40 mL) at 0° C. After the addition, the ice-bath was removed and the mixture was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure to give an oil which crystallized to give the title compound (4.11 g, 95%) as an orange solid.
後処理
- additionAfter the addition
- customthe ice-bath was removed
- customThe solvent was removed under reduced pressure
- customto give an oil which
- customcrystallized
出典と根拠
- ORDレコード
- ord-bd7aea0441774ac8a6d3c5e271cd2f8d
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08772288B2
反応ノート
読み込み中…