Cornforth reagent → 1-(4-Methoxy-2,5-dimethylphenyl)ethanone
反応式
[CH3:1][O:2][C:3]1[C:8]([CH3:9])=[CH:7][C:6]([CH:10]([OH:12])[CH3:11])=[C:5]([CH3:13])[CH:4]=1.[Cr](O[Cr]([O-])(=O)=O)([O-])(=O)=O.[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1>ClCCl>[CH3:1][O:2][C:3]1[C:8]([CH3:9])=[CH:7][C:6]([C:10](=[O:12])[CH3:11])=[C:5]([CH3:13])[CH:4]=1参加物
4
実験手順
A solution of 0.8 g (4.1 mmol) of 1-(4-methoxy-2,5-dimethylphenyl)ethanol obtained in Step 1 in 30 mL of dichloromethane was reacted with 3.0 g (8.2 mmol) of pyridinium dichromate at room temperature for 2 hours with stirring, followed by filtration through celite. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated in a vacuum to afford 1-(4-methoxy-2,5-dimethylphenyl)ethanone as a brown oil (0.54 g, yield: 69%).
後処理
- filtrationfollowed by filtration through celite
- dry with materialThe organic layer was dried over anhydrous magnesium sulfate
- filtrationfiltered
- concentrationconcentrated in a vacuum
出典と根拠
- ORDレコード
- ord-1b1bd11c462f47f8a09a0f1e5a7997ba
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08772290B2
反応ノート
読み込み中…