Hydrogen Peroxide → 2-Amino-4-bromo-6-fluorobenzoic acid

HRID 1619329ノート

反応式

HRID 1619329 の反応式
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6](=[O:12])C(=O)[NH:8]2)=[C:4]([F:13])[CH:3]=1.[OH:14]O>[OH-].[Na+]>[NH2:8][C:9]1[CH:10]=[C:2]([Br:1])[CH:3]=[C:4]([F:13])[C:5]=1[C:6]([OH:12])=[O:14]

参加物

4

反応物 2

HCID 784Hydrogen PeroxideHCID 672585381312454-85-5

生成物 1

HCID 672576072-Amino-4-bromo-6-fluorobenzoic acid

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

To a solution of 6-bromo-4-fluoroindoline-2,3-dione (7.4 g, 31.8 mmol) in 1 M NaOH (100 mL) was added 38% H2O2 (13 mL) dropwise. The resulting solution was stirred at rt for 2 h. The mixture was filtered and the filtrate was acidified using hydrochloric acid (2 N) till pH became around 2. The precipitate was formed and filtered, washed with water, dried under vacuum to give 2.8 g of the desired product. MS (ESI): 232, 234 (MH−).

後処理

  1. filtrationThe mixture was filtered
  2. customThe precipitate was formed
  3. filtrationfiltered
  4. washwashed with water
  5. customdried under vacuum

出典と根拠

ORDレコード
ord-f322590bfeb841a2a8db703f119164dd
出典データセット
uspto-grants-2014_07
特許番号
US08772301B2

反応ノート

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