Dimethyl malonate → 1,3-Dimethyl 2-[(dimethylamino)methylidene]propanedioate

HRID 1619379ノート

反応式

HRID 1619379 の反応式
[C:1]([O:8][CH3:9])(=[O:7])[CH2:2][C:3]([O:5][CH3:6])=[O:4].[CH3:10][N:11]([CH:13](OC)OC)[CH3:12]>>[CH3:10][N:11]([CH:13]=[C:2]([C:1]([O:8][CH3:9])=[O:7])[C:3]([O:5][CH3:6])=[O:4])[CH3:12]

参加物

3

反応物 2

HCID 7943Dimethyl malonateHCID 78373Dimethylformamide dimethyl acetal

生成物 1

HCID 5936031,3-Dimethyl 2-[(dimethylamino)methylidene]propanedioate収率 98.7%

実験手順

A solution of dimethyl malonate (5 g, 37.9 mmol, 1 equiv) in DMF-DMA (11.3 g, 94.8 mmol, 2.5 equiv) was stirred at room temperature overnight. Then the reaction mixture was concentrated to give 7 g of the desired product, which was directly used for the next step without further purification. MS (ESI): 188 (MH+).

後処理

  1. concentrationThen the reaction mixture was concentrated

出典と根拠

ORDレコード
ord-7434af8fe5bc478882cbb6e406ca2e18
出典データセット
uspto-grants-2014_07
特許番号
US08772301B2

反応ノート

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