Hydrochloric Acid → 2-[4-(Benzyloxy)phenyl]propane-1,3-diol

HRID 1619434ノート

反応式

HRID 1619434 の反応式
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]([C:21](OCC)=[O:22])[C:16](OCC)=[O:17])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[BH4-].[Na+].Cl>C(O)C>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH:15]([CH2:21][OH:22])[CH2:16][OH:17])=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 2823246Diethyl 2-(4-(benzyloxy)phenyl)malonateHCID 4311764Sodium borohydride

生成物 1

HCID 675171722-[4-(Benzyloxy)phenyl]propane-1,3-diol収率 96%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
30 °C

実験手順

To a solution of diethyl 2-(4-(benzyloxy)phenyl)malonate (20 gm, 0.0585 mole) in ethanol (200 ml) was added sodium borohydride (17.4 gm, 0.4678 mole) in portions at 0° C. and the reaction mixture was stirred for 4 hrs at 30° C. The reaction mixture was poured into ice cold water, acidified with conc. HCl and extracted with ethyl acetate. The organic extract was successively washed with water & brine, dried over sodium sulfate and concentrated under reduced pressure to provide 14.5 gm of product as white solid.

後処理

  1. additionThe reaction mixture was poured into ice cold water
  2. extractionextracted with ethyl acetate
  3. extractionThe organic extract
  4. washwas successively washed with water & brine
  5. dry with materialdried over sodium sulfate
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-1d33caf6a0ff42b68d335acfda703674
出典データセット
uspto-grants-2014_07
特許番号
US08772302B2

反応ノート

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