(+/-)-{3-Chloro-6-[(4-fluoro-benzenesulfonyl)-methyl-amino]-5,6,7,8-tetrahydro-2,4b-diaza-fluoren-9-yl}-acetic acid → HCID 59471427、化合物
反応式
Cl[C:2]1[N:3]=[CH:4][C:5]2[C:6]([CH2:27][C:28]([OH:30])=[O:29])=[C:7]3[N:12]([C:13]=2[CH:14]=1)[CH2:11][CH:10]([N:15]([S:17]([C:20]1[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=1)(=[O:19])=[O:18])[CH3:16])[CH2:9][CH2:8]3>CO.[Pd]>[F:26][C:23]1[CH:22]=[CH:21][C:20]([S:17]([N:15]([CH3:16])[CH:10]2[CH2:9][CH2:8][C:7]3[N:12]([C:4]4[N:3]=[CH:2][CH:14]=[CH:13][C:5]=4[C:6]=3[CH2:27][C:28]([OH:30])=[O:29])[CH2:11]2)(=[O:18])=[O:19])=[CH:25][CH:24]=1参加物
4
実験手順
A solution of (±)-{3-chloro-6-[(4-fluoro-benzenesulfonyl)-methyl-amino]-5,6,7,8-tetrahydro-2,4b-diaza-fluoren-9-yl}-acetic acid (2 mg) and 2 mg of Pd/C (20%) in 0.5 mL of MeOH was stirred under Hz (balloon pressure) for 8 h. The suspension was filtered through celite and the filtrate was concentrated to give the title compound. MS (ES): 418.0 (M+1).