To a solution of (R)-quinuclidin-3-yl 2-phenyl-2-(phenylsulfonamido)acetate (C64) (96 mg, 0.24 mmol) in EtOAc (1.6 ml) and acetonitrile (0.8 ml), was added 2-chloro-1-phenylethanone (40.8 mg, 0.26 mmol). The solution was stirred at RT overnight. The solution was concentrated under vacuum and the crude was purified by flash chromatography (DCM/MeOH=95/5 to 9/1) to obtain (3R)-1-(2-oxo-2-phenylethyl)-3-(2-phenyl-2-(phenylsulfonamido)acetoxy)-1-azoniabicyclo[2.2.2]octane chloride (99 mg; 74% yield).
