HCID 66698120、化合物 → N-methylpyrrolidine-3-sulfonamide
反応式
[CH3:1][NH:2][S:3]([CH:6]1[CH2:10][CH2:9][N:8](C(OCC2C=CC=CC=2)=O)[CH2:7]1)(=[O:5])=[O:4]>CO.[Pd]>[CH3:1][NH:2][S:3]([CH:6]1[CH2:10][CH2:9][NH:8][CH2:7]1)(=[O:5])=[O:4]参加物
4
実験手順
A mixture of the above benzyl carbamate (173 mg, 0.580 mmol) and 10% Pd on carbon in MeOH (15 mL) was hydrogenated for 24 hrs. The reaction mixture was filtered through celite, the celite pad was washed with MeOH, and the solvent was removed under vacuum to give N-methyl-3-pyrrolidinesulfonamide (92 mg, 97%) which was used in the next step without further purification. 1H NMR (DMSO-d6) δ 6.89 (br s, 1H), 3.62 (qd, J=8.9, 6.3 Hz, 1H), 2.99 (m, 2H), 2.82 (m, 1H), 2.72 (m, 1H), 2.59 (s, 3H), 1.95 (m, 2H).
後処理
- filtrationThe reaction mixture was filtered through celite
- washthe celite pad was washed with MeOH
- customthe solvent was removed under vacuum
出典と根拠
- ORDレコード
- ord-0e7b1dd3f3d64d15b7152a0321449c19
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08772287B2
反応ノート
読み込み中…