Cycloheptylamine → 1-Cycloheptyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester
反応式
[C:1]([O:10][CH3:11])(=[O:9])[C:2]([CH2:4][C:5](OC)=[O:6])=[CH2:3].[CH:12]1([NH2:19])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>CO>[CH3:11][O:10][C:1]([CH:2]1[CH2:4][C:5](=[O:6])[N:19]([CH:12]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)[CH2:3]1)=[O:9]参加物
4
実験手順
A solution of dimethyl itaconate (0.5 g, 3.16 mmoles), cycloheptylamine (0.357 g, 3.16 mmoles) in methanol (5 mL) was heated at 85° C. for eighteen hours. The solvent was evaporated in vacuo and the resulting crude product was purified by flash chromatography (hexanes/ethyl acetate 80:20 to 20:80) to give the title compound as a colorless oil.
後処理
- customThe solvent was evaporated in vacuo
- customthe resulting crude product was purified by flash chromatography (hexanes/ethyl acetate 80:20 to 20:80)
出典と根拠
- ORDレコード
- ord-3d2c5d232e3848caaad5f18d300787d9
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07737137B2
反応ノート
読み込み中…