6-(4-benzylamino-3-hydroxy-phenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one → 6-(4-amino-3-hydroxy-phenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one

HRID 1619967ノート

反応式

HRID 1619967 の反応式
C([NH:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:16]([CH3:22])[CH2:17][C:18](=[O:21])[NH:19][N:20]=2)=[CH:11][C:10]=1[OH:23])C1C=CC=CC=1.[H][H]>[Pd].CO>[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:16]([CH3:22])[CH2:17][C:18](=[O:21])[NH:19][N:20]=2)=[CH:11][C:10]=1[OH:23]

参加物

5

反応物 2

HCID 674671166-(4-benzylamino-3-hydroxy-phenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-oneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 179934936-(4-amino-3-hydroxy-phenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

43.0 g (139 mmol) 6-(4-benzylamino-3-hydroxy-phenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one, 2.2 g of 10% palladium/charcoal and 400 ml of methanol are hydrogenated together for 24 h at RT and 3.45 bar of hydrogen pressure. The catalyst is filtered off and the filtrate is concentrated by rotary evaporation i. V., the residue is triturated with ethyl acetate, suction filtered and then dried at 50° C. in the vacuum dryer.

後処理

  1. filtrationThe catalyst is filtered off
  2. concentrationthe filtrate is concentrated by rotary evaporation i
  3. custom, the residue is triturated with ethyl acetate, suction
  4. filtrationfiltered
  5. customdried at 50° C. in the vacuum dryer

出典と根拠

ORDレコード
ord-3cdd97063bad496ca269bb6d46ec3bbe
出典データセット
uspto-grants-2014_07
特許番号
US08772323B2

反応ノート

読み込み中…