Ethyl 4-oxocyclohexanecarboxylate → Cyclohexanecarboxylic acid, 4-(hydroxyimino)-, ethyl ester

HRID 1620558ノート

反応式

HRID 1620558 の反応式
Cl.[OH:2][NH2:3].C([O-])(=O)C.[Na+].O=[C:10]1[CH2:15][CH2:14][CH:13]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:12][CH2:11]1>O>[OH:2][N:3]=[C:10]1[CH2:15][CH2:14][CH:13]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:12][CH2:11]1

参加物

5

反応物 3

HCID 317638Ethyl 4-oxocyclohexanecarboxylateHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium Acetate

生成物 1

HCID 11593553Cyclohexanecarboxylic acid, 4-(hydroxyimino)-, ethyl ester収率 100%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of hydroxyamine hydrochloride (15.3 g) and sodium acetate (24.1 g) in water (58.8 mL) was added dropwise ethyl 4-oxocyclohexanecarboxylate (25.0 g) over 20 min. The reaction mixture was stirred at room temperature overnight, and extracted with tert-butyl methyl ether. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (27.2 g).

後処理

  1. extractionextracted with tert-butyl methyl ether
  2. washThe extract was washed with saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-81e6a70862f74c03ae8608fd9d89f527
出典データセット
uspto-grants-2014_07
特許番号
US08772277B2

反応ノート

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