Ethyl 4-oxocyclohexanecarboxylate → Cyclohexanecarboxylic acid, 4-(hydroxyimino)-, ethyl ester

HRID 1620630ノート

反応式

HRID 1620630 の反応式
Cl.[OH:2][NH2:3].C([O-])(=O)C.[Na+].O=[C:10]1[CH2:15][CH2:14][CH:13]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:12][CH2:11]1>O>[OH:2][N:3]=[C:10]1[CH2:15][CH2:14][CH:13]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:12][CH2:11]1

参加物

5

反応物 3

HCID 317638Ethyl 4-oxocyclohexanecarboxylateHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium Acetate

生成物 1

HCID 11593553Cyclohexanecarboxylic acid, 4-(hydroxyimino)-, ethyl ester収率 100%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of hydroxyamine hydrochloride (15.3 g) and sodium acetate (24.1 g) in water (60 mL) was added ethyl 4-oxocyclohexanecarboxylate (25.0 g) over 20 min. The reaction mixture was stirred at room temperature overnight, and extracted with tert-butyl methyl ether. The extract was washed with saturated brine, and dried over magnesium sulfate to give the title compound (27.2 g).

後処理

  1. extractionextracted with tert-butyl methyl ether
  2. washThe extract was washed with saturated brine
  3. dry with materialdried over magnesium sulfate

出典と根拠

ORDレコード
ord-ecb204521782467496900e40b760d6d4
出典データセット
uspto-grants-2014_07
特許番号
US08772277B2

反応ノート

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