Potassium hydroxy sulfite → 4-{[5-(Methylsulfinyl)-1,3-thiazol-2-yl]carbamoyl}phenyl acetate

HRID 1620886

反応式

HRID 1620886 の反応式
[OH:1]OS([O-])=O.[K+].[C:7]([O:10][C:11]1[CH:16]=[CH:15][C:14]([C:17](=[O:26])[NH:18][C:19]2[S:20][C:21]([S:24][CH3:25])=[CH:22][N:23]=2)=[CH:13][CH:12]=1)(=[O:9])[CH3:8]>C(Cl)(Cl)Cl>[C:7]([O:10][C:11]1[CH:12]=[CH:13][C:14]([C:17](=[O:26])[NH:18][C:19]2[S:20][C:21]([S:24]([CH3:25])=[O:1])=[CH:22][N:23]=2)=[CH:15][CH:16]=1)(=[O:9])[CH3:8]

参加物

4

反応物 2

HCID 23707502Potassium hydroxy sulfiteHCID 575718204-{[5-(Methylsulfanyl)-1,3-thiazol-2-yl]carbamoyl}phenyl acetate

生成物 1

HCID 569693934-{[5-(Methylsulfinyl)-1,3-thiazol-2-yl]carbamoyl}phenyl acetate

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Using the Oxone® procedure as described in section 1.5.1.7 for the synthesis of compound (I), 515 (0.841 g, 2.73 mmol) gives crude 7. The crude product is stirred with chloroform (50 mL) and the suspension is filtered. The pad is washed once with chloroform and air dried to give pure 7 (0.35 g) as a white solid.

後処理

  1. customgives crude 7
  2. filtrationthe suspension is filtered
  3. washThe pad is washed once with chloroform and air
  4. customdried

出典と根拠

ORDレコード
ord-7e3ee9d730574924bdaf720001ab6ccb
出典データセット
uspto-grants-2014_07
特許番号
US08772502B2

関連ノート

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