Hydrochloric Acid → 2-hydroxy-N-(5-(methylsulfinyl)thiazol-2-yl)benzamide

HRID 1620892ノート

反応式

HRID 1620892 の反応式
C([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11](=[O:21])[NH:12][C:13]1[S:14][C:15]([S:18]([CH3:20])=[O:19])=[CH:16][N:17]=1)(=O)C.Cl>C1COCC1>[OH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]([NH:12][C:13]1[S:14][C:15]([S:18]([CH3:20])=[O:19])=[CH:16][N:17]=1)=[O:21]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 569693972-(5-(Methylsulfinyl)thiazol-2-ylcarbamoyl)phenyl acetate

生成物 1

HCID 569696152-hydroxy-N-(5-(methylsulfinyl)thiazol-2-yl)benzamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 11 (1.0 g, 3.1 mmol) is dissolved in THF (20 mL) and is added under stirring to 2M HCl (100 mL). The reaction is refluxed for one hour and is allowed to cool under stirring over one hour. The product is filtered using a sintered glass funnel, washed with distilled water and THF and dried in high vacuum and affords 12 as a colorless solid.

後処理

  1. additionis added
  2. temperatureThe reaction is refluxed for one hour
  3. temperatureto cool
  4. filtrationThe product is filtered
  5. washwashed with distilled water and THF
  6. customdried in high vacuum

出典と根拠

ORDレコード
ord-7aab2f2e0d7e4a35b9fb58228235f10f
出典データセット
uspto-grants-2014_07
特許番号
US08772502B2

反応ノート

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