Hydrochloric Acid → [(2,3-Difluorobenzoyl)amino]acetic acid

HRID 1621179

反応式

HRID 1621179 の反応式
[F:1][C:2]1[C:15]([F:16])=[CH:14][CH:13]=[CH:12][C:3]=1[C:4]([NH:6][CH2:7][C:8]([O:10]C)=[O:9])=[O:5].[OH-].[Li+].Cl>CO.O>[F:1][C:2]1[C:15]([F:16])=[CH:14][CH:13]=[CH:12][C:3]=1[C:4]([NH:6][CH2:7][C:8]([OH:10])=[O:9])=[O:5]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 59816250Methyl [(2,3-difluorobenzoyl)amino]acetate

生成物 1

HCID 59816243[(2,3-Difluorobenzoyl)amino]acetic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒2 回

実験手順

To a solution of methyl [(2,3-difluorobenzoyl)amino]acetate (0.250 g, 1.1 mmol) in methanol (7 mL) were added lithium hydroxide (0.053 g, 2.2 mmol) and water (3 mL). The reaction mixture was allowed to stir overnight. The mixture was diluted with water (20 mL) and acidified with 1N HCl (5 mL). The product was partitioned into DCM/methanol (4:1). The organic layer was dried over sodium sulfate and the solvent removed to give [(2,3-difluorobenzoyl)amino]acetic acid which was used in the next step without purification.

後処理

  1. customThe product was partitioned into DCM/methanol (4:1)
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. customthe solvent removed

出典と根拠

ORDレコード
ord-5e5e4963e62247e5bafe92166b9bd455
出典データセット
uspto-grants-2014_07
特許番号
US08772536B2

関連ノート

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