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6-Chloro-2-(trifluoromethyl)pyrimidin-4-amine → 6-(2-Fluoropyridin-3-yl)-2-(trifluoromethyl)pyrimidin-4-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-Chloro-2-(trifluoromethyl)pyrimidin-4-amine | HCID 245271 | — |
| 反応物 | 2-Fluoropyridine-3-boronic acid | HCID 2783270 | — |
| 生成物 | 6-(2-Fluoropyridin-3-yl)-2-(trifluoromethyl)pyrimidin-4-amine | HCID 66599939 | — |
反応手順
The title compound was prepared in an analogous manner to that described above in Example 4 using 2-fluoropyridin-3-ylboronic acid and 6-chloro-2-(trifluoromethyl)pyrimidin-4-amine (SynChem. Inc., Elk Grove Village, Ill.), and the desired product 6-(2-fluoropyridin-3-yl)-2-(trifluoromethyl)pyrimidin-4-amine was isolated as a white solid (34%). LCMS (API-ES) m/z 259 (M+H)+; 1H NMR (400 MHz, d6-DMSO) δ 8.57 (t, J=8.80 Hz, 1H) 8.38 (d, J=3.91 Hz, 1H) 7.83 (br. s., 2H) 7.46-7.63 (m, 1H) 7.15 (s, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08772480B2 |
| 出典データセット | uspto-grants-2014_07 |
| ORD ID | ord-935bef867de748c9bf110681df07ede1 |
| 出典メモ | uspto-grants-2014_07 |